Kiyotaka Nakagawa Selected Research

Tocotrienols

10/2016	δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.
1/2016	A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells.
8/2015	δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy.
10/2014	Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid.
1/2013	Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice.
1/2013	γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.
6/2010	alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells.
2/2009	Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol).
11/2008	Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha.
9/2006	Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol.

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Kiyotaka Nakagawa Research Topics

Disease

24	Neoplasms (Cancer) 01/2022 - 07/2003
9	Adenocarcinoma 01/2016 - 01/2004
8	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 04/2011
8	Atherosclerosis 01/2017 - 05/2009
7	Body Weight (Weight, Body) 05/2019 - 12/2002
6	Inflammation (Inflammations) 01/2022 - 06/2010
6	Obesity 10/2021 - 08/2013
5	Hepatocellular Carcinoma (Hepatoma) 10/2016 - 05/2012
4	Dementia (Dementias) 01/2018 - 10/2008
4	Diabetes Mellitus 10/2012 - 07/2007
3	Type 2 Diabetes Mellitus (MODY) 01/2019 - 10/2002
3	Diabetes Complications 07/2012 - 08/2010
3	Infections 01/2010 - 03/2008
3	Vascular Diseases (Vascular Disease) 06/2005 - 12/2002
2	Hypoxia (Hypoxemia) 01/2022 - 11/2008
2	Alcoholic Fatty Liver 01/2022 - 01/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 07/2017
2	Colitis 11/2021 - 07/2017
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 12/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2017 - 02/2016
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2014 - 07/2012
2	Hyperglycemia 10/2011 - 08/2011
2	Hyperplasia 08/2010 - 06/2010
2	Weight Loss (Weight Reduction) 08/2006 - 11/2005
1	Fibrosis (Cirrhosis) 01/2022
1	Skin Abnormalities 11/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2021
1	Colonic Neoplasms (Colon Cancer) 02/2021
1	Brain Diseases (Brain Disorder) 01/2021
1	Aberrant Crypt Foci 01/2021
1	Carcinogenesis 01/2021
1	Wounds and Injuries (Trauma) 09/2020
1	Cataract (Cataracts) 01/2020
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2020
1	Hypotrichosis 01/2020

Drug/Important Bio-Agent (IBA)

12	LipidsIBA 01/2022 - 11/2005
12	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 10/2008
12	TocotrienolsIBA 10/2016 - 07/2003
8	1-Deoxynojirimycin (1 Deoxynojirimycin)IBA 05/2020 - 07/2007
8	Telomerase (Telomerase Reverse Transcriptase)IBA 02/2018 - 01/2004
6	phosphatidylcholine hydroperoxideIBA 03/2015 - 12/2002
5	Vitamin E FDA LinkGeneric 08/2015 - 11/2008
4	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022 - 01/2004
4	Messenger RNA (mRNA)IBA 01/2022 - 11/2008
4	phosphatidal ethanolaminesIBA 01/2022 - 01/2016
4	Ethanolamine (Colamine)IBA 11/2021 - 02/2016
4	CholesterolIBA 01/2020 - 03/2004
4	Triglycerides (Triacylglycerol)IBA 01/2017 - 08/2006
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2017 - 01/2004
4	phosphatidylethanolamineIBA 01/2017 - 08/2010
4	N- (1,6- dideoxyfructopyranosyl)- 1,3- dioleoyl- 2- phosphatidylethanolamineIBA 07/2012 - 12/2003
4	Proteins (Proteins, Gene)FDA Link 04/2012 - 11/2008
3	PlasmalogensIBA 01/2022 - 01/2016
3	Glycerophospholipids (Phosphoglycerides)IBA 11/2021 - 02/2016
3	vinyl ether (divinyl ether)IBA 11/2021 - 01/2021
3	AntioxidantsIBA 02/2018 - 11/2009
3	CurcuminIBA 01/2018 - 05/2014
3	PolyphenolsIBA 01/2017 - 01/2013
3	ferulic acid (sodium ferulate)IBA 09/2016 - 10/2014
3	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2016 - 05/2009
3	Glycoside Hydrolases (Endoglycosidases)IBA 05/2013 - 12/2009
3	Blood Glucose (Blood Sugar)IBA 10/2012 - 07/2007
3	Tocopherols (Tocopherol)IBA 06/2010 - 02/2007
3	delta tocotrienolIBA 06/2010 - 09/2006
2	choline plasmalogensIBA 01/2022 - 02/2017
2	Ethanol (Ethyl Alcohol)IBA 01/2022 - 01/2013
2	stearic acid (magnesium stearate)FDA LinkGeneric 01/2021 - 01/2017
2	Biological ProductsIBA 01/2020 - 11/2009
2	EnzymesIBA 01/2020 - 07/2012
2	Pharmaceutical PreparationsIBA 01/2020 - 09/2006
2	SqualeneIBA 12/2019 - 01/2019
2	GlucosidasesIBA 01/2019 - 07/2007
2	sesaminIBA 02/2018 - 09/2016
2	astaxanthine (astaxanthin)IBA 02/2018 - 06/2011
2	InterferonsIBA 01/2018 - 09/2009
2	InterleukinsIBA 01/2018 - 09/2009
2	Caspase 3 (Caspase-3)IBA 02/2016 - 08/2015
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2016 - 01/2013
2	Antineoplastic Agents (Antineoplastics)IBA 08/2015 - 01/2013
2	Biomarkers (Surrogate Marker)IBA 01/2014 - 04/2012
2	Picryl Chloride (Trinitrochlorobenzene)IBA 01/2013 - 03/2012
2	Streptozocin (Streptozotocin)FDA Link 04/2012 - 10/2011
2	Glucose (Dextrose)FDA LinkGeneric 03/2012 - 08/2011
2	LuteinIBA 01/2012 - 11/2009
2	Angiogenesis InhibitorsIBA 02/2009 - 11/2008
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2009 - 08/2008
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2008 - 08/2008
1	lysoplasmalogenase (alkenylglycerophosphocholine hydrolase)IBA 01/2022
1	Phospholipases (Phospholipase)IBA 01/2022
1	Dextran SulfateIBA 11/2021
1	AlkaloidsIBA 10/2021
1	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA 01/2021
1	Ether (Diethyl Ether)IBA 01/2021
1	Dimenhydrinate (DMH)FDA LinkGeneric 01/2021
1	Testosterone (Sustanon)FDA Link 01/2020
1	Glutathione (Reduced Glutathione)IBA 01/2020
1	Tamoxifen FDA LinkGeneric 01/2020

Therapy/Procedure

7	Therapeutics 09/2016 - 08/2007
4	Oral Administration 05/2019 - 11/2009
2	Caloric Restriction 01/2018 - 07/2017